S100A8蛋白在口腔鳞癌中的表达及临床意义

摘要

采用免疫组化法和免疫印迹法检测S100A8蛋白在30例正常口腔组织及35例口腔鳞癌组织中的表达.35例OSCC组织中S100A8蛋白阳性表达率为68. 5％,在正常组织中的表达率为36. 7％(P ＜ 0. 05),S100A8可能参与OSCC的发生与发展.%The expression of calcium binding protein S100A8 in 30 controls of normal oral tissue and 35 cases of OSCC was detected by immunohistochemical staining and Western blot respectively. The positive expression of S100A8 protein in OSCC and the controls was 68. 5％ and 36. 7％ respectively(P ＜ 0. 05). S100A8 may play a role in the development of OSCC.