Objective To study the expression of β-catenin and p5 3 protein in oral squamous cell carcino-ma (OSCC) and their clinical significance .Methods Immunohistochemical analysis was applied to detect the expressions of β-catenin and p5 3 protein in 5 5 cases of oral squamous cell carcinoma and 1 5 cases of normal oral mucous membrane .Results (1 ) Abnormal expression of β-catenin was described as reduced or absent mem-brane staining and altered cytoplasmic and/or nuclear accumulation and was detected in7 0 .9% of 5 5 cases in OS-CC .Abnormalβ-catenin expression was significantly associated with moderately or poorly differentiated carci-noma( P<0 .0 5 ) ,however ,there was no a statistically significant association with lymph node metastasis ( P>0 .0 5 ) .(2 ) The positive rate of p5 3 protein was 6 7 .6% and significantly higher than that in normal epithelium ( P<0 .0 5 ) .The expression of p5 3 protein in the clinical stage Ⅲ ,Ⅳ were significantly higher than that in clin-ical stage Ⅰ ,Ⅱ(P<0 .05 ) .(3 )There was correlation between the expression of β-catenin and the expression of p53 protein(r=0 .373 ,P<0 .05 ) .Conclusion Abnormal expression of β-catenin and overexpression of p53 protein may be individually or conjunctly involved in the course of pathogenesis and development of oral squa -mous cell carcinoma .%目的：研究口腔鳞癌组织中β－catenin和p53蛋白的表达及其与临床病理学特征的关系，探讨β－catenin和p53蛋白在口腔鳞癌发生中的作用。方法采用免疫组织化学方法检测55例原发性口腔鳞癌组织以及15例正常口腔黏膜组织中β－catenin 和p53蛋白的表达。结果（1）β－catenin在口腔鳞癌组织中显示细胞膜表达减弱或消失，并出现胞质和（或）胞核内的异常蓄积。β－catenin在口腔鳞癌组织中的异常表达率为70．9％，明显高于正常对照组（P＜0．05），而且在口腔鳞癌中－低分化型的异常表达明显高于高分化型，与肿瘤的组织分化程度有关（P＜0．05），但与有无淋巴结转移差别无统计学意义（P＞0．05）。（2） p53蛋白的阳性表达率为67．2％，显著高于正常口腔黏膜组织（P＜0．05）。p53蛋白在口腔鳞癌临床Ⅲ、Ⅳ期的过度表达明显高于Ⅰ、Ⅱ期，差异有统计学意义（P＜0．05）。在有无淋巴结转移组间p53蛋白的阳性表达差异无统计学意义（ P＞0．05）。（3）β－catenin异常表达与p53蛋白阳性表达之间呈正相关（ r＝0．373，P＜0．05）。结论β－catenin和p53蛋白单独或可能协同作用参与口腔鳞癌的发生发展。
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