宫颈上皮内瘤变Ⅱ／Ⅲ级及宫颈癌中人乳头瘤病毒基因型分布的比较

摘要

Objective To explore the distributions of genotypes of HPV infection in CIN and cervical carcinoma. Methods Cervical exfoliated cells were collected from 365 patients with abnormal cervical histology , and subjected to genotyping assay. Results The most prevalent HPV types were 16, 18,52, 58 and 33. The prevalence ratio of HPV 33,52,58 was signi cantly lower in squamous cell carcinoma. Multiple infections decreased from CIN II/III to cervical cancer. Conclusion Besides HPV 16/18, the 52/58/33 subtypes are also important in the development of cervical cancer.%目的：研究宫颈癌及CIN 中人乳头瘤病毒（HPV）基因型分布。方法：对365例患者（103例 CINⅡ、128例CIN Ⅲ及134例宫颈癌）宫颈脱落细胞进行 HPV 基因检测分型，统计阳性率，分析 HPV 与病变程度间的相关性。结果：（1）3组最常见的4种 HPV 分别依次为：HPV16、HPV52、HPV58、HPV33；HPV16、HPV58、HPV33、HPV52；HPV16、HPV18、HPV58、HPV33。（2）CIN Ⅲ组与CIN Ⅱ组比较，前者HPV58阳性率高，HPV52阳性率低；宫颈鳞癌组与 CIN Ⅲ组比较，前者 HPV16阳性率高，HPV33、HPV 52和 HPV58阳性率低（P ＜0．05）。（3）宫颈癌组较CIN Ⅱ／Ⅲ组多重HPV感染率下降。结论：HPV16／18是宫颈癌最关键的诱发因素，HPV33／52／58亦属常见高危亚型，应同时兼顾。