“一锅法”合成2,3-二氢-4(1H)-喹唑啉酮衍生物

摘要

在醇水溶液中,氯化铝可有效催化靛红酸酐、芳香醛和铵盐/伯胺三组分“一锅法”合成单取代和双取代2,3-二氢-4(1H)-喹唑啉酮衍生物.产品结构经IR,1H-NMR,13C- NMR,质谱和元素分析进行表征.与已报道的合成方法相比,该方法具有反应时间短、收率高、实验操作和后处理步骤简单、对环境友好等优点.%2,3 - Dihydro - 4(1H) - quinazolinones derivatives were synthesized efficiently by a three components one-pot reaction of isatoic anhydride, aromatic aldehydes, ammonium salts or primary amines in the presence of aluminum chloride in alcohol-water solution. The structures of products were characterized by IR, 1H - NMR, 13C-NMR, MS techniques and elemental analysis. Compared to the reported methods, this protocol have advantages of short reaction time, high yield, simple experimental and work-up procedures, and environmentally benign procedure.