首发精神分裂症患者血清 β2微球蛋白的变化

摘要

Objective To explore the changes and clinical significance of β2 -microglobulin (β2 -MG) in patients with first episode schizophrenia.Methods β2 -MG was examined in schizophrenia pa-tients (n= 60)and healthy controls (n= 60).PANSS was used to assess the clinical symptoms in schiz-ophrenia patients.Results Serumβ2 -MG was significantly higher in schizophrenia patients than healthy con-trols (P< 0.05);there was a significant positive correlation betweenβ2 -MG level and PANSS score (r =0.477 ,P< 0.001) ,negative score (r= 0.422 ,P= 0.001) and general pathology score (r= 0.391 ,P=0.002);there was no correlation with the positive scores (r= 0.107 ,P= 0.418).Conclusions β2 -MG may have a potential role in the pathogenesis of schizophrenia.Its concentration can be used as an indica-tor of immune function in schizophrenia patients.%目的 探讨精神分裂症患者血清β2微球蛋白(β2-MG)的变化及其临床意义.方法 随机选取60例精神分裂症患者为研究组,60名健康人为对照组,在基线测定两组人群血清β2-M G水平,并应用阳性与阴性症状量表(PANSS)评定精神分裂症患者的精神症状.结果 研究组血清β2-MG水平较对照组明显升高,差异有统计学意义(P<0.05);研究组血清β2-MG水平与PANSS总分(r=0.477,P<0.001)、阴性分(r=0.422,P=0.001)和一般精神病理分(r=0.391,P=0.002)呈正相关,与阳性分无相关性(r=0.107,P=0.418).结论 血清β2-M G在精神分裂症的发病过程中可能起到重要作用,其浓度可作为评定精神分裂症患者免疫功能的指标之一.