体重指数与乳腺癌发病风险的病例对照研究

摘要

Objective:To study the association between BMI and risk of breast cancer.Methods:A case-control study (1 ∶ 1 matched) was conducted between June 2008 and August 2009 in the First Hospital of China Medical University.Three hundred and thirty breast cancer patients and 330 healthy people from the Health Examination Center were matched with age(-5 years old),sex and region.Information was collected on their BMI index at 21 years old,5 years ago and now.Conditional logistic regression was applied to analyze the risk factors of breast cancer.Results:The adjusted ORs and 95％ CI of BMI at 5 years ago,menopause and passive smoking were 1.465 (1.016-2.112),2.347 (1.459-3.777) and 1.384 (1.009-1.897),respectively.Conclusion:Overweight at 5 years ago was associated with an increased risk of breast cancer in Chinese women,menopause and passive smoking were also the risk factors of breast cancer.%目的:探讨体重指数(BMI)与乳腺癌发病风险的关系.方法:采用1∶1匹配病例对照研究,收集2008年6月至2009年8月由中国医科大学附属第一医院确诊的女性乳腺癌患者330例及同期就诊体检中心的健康人群330例,调查患者21岁时、5年前及目前的BMI指数.采用多因素条件Logistic回归分析乳腺癌发病风险的影响因素.结果:5年前BMI指数、绝经、被动吸烟的OR值及95％可信区间分别是1.465(1.016-2.112)、2.347(1.459-3.777)和1.384(1.009-1.897).结论:5年前超重可明显增加乳腺癌发病的危险,绝经和暴露被动吸烟是乳腺癌发病的危险因素.