肺癌灌注成像参数与患者生存期的关系

摘要

目的：分析不同病理类型肺癌 CT 灌注参数与患者生存期的相关性。方法：对58例病理证实为肺癌的患者行螺旋 CT 灌注成像，量化分析灌注参数血容量（blood volume，BV）、血流量（blood flow，BF）、对比剂到达峰值时间（time to peak，TTP）、强化峰值（peak enhance - mentimage，PEI），与患者生存期做相关性分析。结果：肺鳞癌 BV 为47.90±20.50，BF 为27.75±11.75，TTP 29.65±29.05 PEI 为44.50±25.35，鳞癌 BV 与患者生存期成负相关（P ＜0.05）；肺腺癌 BV 为36.32±32.15，BF 为75.00±25.70，TTP 为20.98±16.62， PEI 为52.05±21.57，肺腺癌 BV 与患者生存期成负相关（P ＜0.05）。结论：肺癌部分灌注参数与患者的生存期有关，对临床预后评估具有较大价值。%Objective:To investigate the relationship between 16 - slice spiral CT perfusion imaging and lifetime in patients with different subtypes of lung cancer. Methods:Fifty - eight patients with lung cancer underwent spiral CT perfusion imaging. Blood flow(BF),blood volume(BV),and mean transit time(MTT)were quantitatively ana-tyzed also the between pathological. Then correlation analysis of respective perfusion parameters and the lifetime. Re-sults:BV was 47. 90 ± 20. 50,BF was 27. 75 ± 11. 75,TTP 29. 65 ± 29. 05 and PEI 44. 50 ± 25. 35 in the lung squa-mous cell carcinoma. There was a negative correlation between BV and the lifetime in the lung squamous cell carcino-ma. BV was 36. 32 ± 32. 15,BF 75. 00 ± 25. 70,TTP 20. 98 ± 16. 62 and PEI was 52. 05 ± 21. 57 in the lung adeno-carcinoma. There was a negative correlation between BV and the lifetime in the lung adenocarcinoma. Conclusion:Some of the perfusion parameters were associated with the lifetime and may have important value for the prognosis of lung cancer.