结核分枝杆菌中 O－甘露糖基化蛋白功能的研究进展

摘要

O-mannosylation decoration of proteins not only widely exists in fungal and mammalian cells, but also ex-ists in prokaryotes, e.g.Mycobacterium, Corynebaterium and Streptomyces, especially in Mycobacterium tuberculosis that causes human illness and draw studies the most.Many O-mannosylated proteins play important role during mutual actions in M.tuberculosis virulence and the host.Advances in biological function of O-mannosylated proteins in M. tuberculosis were summarized in this paper.%蛋白质的O－甘露糖基化修饰不仅在真菌和哺乳类细胞中广泛存在，在原核生物中例如分枝杆菌属、棒状杆菌属和链霉菌属中也存在，尤其在引起人类疾病的结核分枝杆菌中研究最多。许多O－甘露糖基化蛋白在结核分枝杆菌毒力以及与宿主相互作用过程中发挥了重要作用。本文就结核分枝杆菌中O－甘露糖基化蛋白生物学功能的进展加以综述。