术前中性粒细胞／淋巴细胞比值对非肌层浸润性膀胱癌术后预后评估价值

摘要

目的：探讨术前中性粒细胞／淋巴细胞比值对非肌层浸润性膀胱癌术后预后评估价值。方法：选择157例行膀胱部分切除或经尿道膀胱肿瘤切除术治疗的患者。测定NLR ，术后随访。比较低NLR组与高NLR组的临床特征及1年、3年、5年无复发生存率情况。结果：高NLR组肿瘤分期分布在T3和T4的比例、肿瘤分级在G3的比例、低分化比例、有淋巴结转移比例、肾积水比例、围手术期间输血比例、切缘阳性比例明显高于低 NLR组（P＜0．05），高NLR组患者3年、5年无复发生存率显著低于低NLR组（P＜0．05）。结论：术前监测非肌层浸润性膀胱癌患者NLR值，评估患者机体对肿瘤的免疫状态，评估其术后复发风险，术前采取合理的治疗方案，以改善患者预后。%Objective :To investigate prognostic postoperative estimated value of ratio of preoperative neutrophil/lym‐phocyte for non muscle invasive bladder cancer .Methods :157 patients with partial resection of bladder or transurethral resection of bladder tumor treatment were selected .They were determined NLR and postoperative followed‐up .Situa‐tion of clinical features ,1 years ,3 years ,5 years recurrence free survival rate were compared between low NLR group and high NLR group .Results:Ratio of T3 ,T4 of Tumor staging ,ratio of G3 of tumor grading ,ratio of poorly differenti‐ated ,ratio of lymphatic metastasis ,ratio of hydronephrosis ,ratio of blood transfusion in peri operation period ,incisal edge ratio of positive were significantly higher than those of low NLR group (P<0 .05) ,3 years ,5 years recurrence free survival rate of patients in high NLR group were significantly lower than those of low NLR group (P<0 .05) .Conclu‐sion:Monitoring NLR of non muscle invasive bladder cancer patients before operation ,evaluating immune state of the patient’s body for tumor .Evaluating risk of recurrence after operation .Carrying out reasonable treatment scheme be‐fore operation ,to improve prognosis of patients .