组织蛋白酶K在慢性肾脏病中的检测意义

摘要

目的:探讨组织蛋白酶K(Cathepsins K,CatK)在慢性肾脏病(CKD)中的检测意义.方法:随机抽取2015年7-12月在本院门诊治疗的CKD患者91例(CKD组),根据骨密度测量结果将患者分为三组:骨密度正常组(A组)、骨密度降低组(B组)和骨质疏松(Osteoporosis OP)组(C组).同时随机选取30例健康人作为对照组.所有对象入院后即抽血查CatK、Cr、BUN、Cys C及PTH等水平.结果:(1)CKD组CatK、Cr、BUN、Cys C及PTH水平均高于对照组,差异有统计学意义(P<0.05);(2)CatK水平C组高于B组及A组,B组高于A组,差异有统计学意义(P<0.05);(3)PTH水平C组高于B组及A组,B组高于A组,差异有统计学意义(P<0.05);(4)CatK与Cr成正相关,相关系数r=0.648(P<0.01);CatK与BUN成正相关,相关系数r=0.488(P<0.01);CatK与Cys C成正相关, 相关系数r=0.438(P<0.01);CatK与PTH成正相关, 相关系数r=0.294(P<0.01).结论:检测CatK有助于判断CKD患者并发OP的可能性及严重性;PTH可能对CatK的分泌释放具有调节作用.%Objective:To observe The significance of detection of cathepsins K in chronic kidney disease.Methods:Slecting 91 patients(CKD group) with chronic kidney disease and devide 3 groups according to the results of bone mineral density measurement:Bone density normal group (A group),Bone mineral density reduction group (B group) and osteoporosis group (C group);slecting 30 healhty persons as the control group.Results:CatK,Cr,BUN,Cys and PTH of CKD groups are higher than control group significance(P<0.05);(2)CatK of C groups are higher than A group and B group, CatK of B groups are higher than A group(P<0.05);(3)PTH of C groups are higher than A group and B group, PTH of B groups are higher than A group(P<0.05);(4)CatK was positively correlated with serum Cr,r=0.648 (P<0.01),CatK was positively correlated with serum BUN,r=0.488 (P<0.01),CatK was positively correlated with serum Cys C,r=0.438 (P<0.01),CatK was positively correlated with serum PTH,r=0.294(P<0.01).Conclusion:Detection of CatK is helpful to judge the possibility of CKD in patients with OP and severity,PTH may regulate the secretion of CatK.