Wilson病Kayser-Fleischer环相关因素分析

摘要

Objective To probe into clinical features and related factors of Kayser-Fleischer(K-F) ring in patients with Wilson's disease(WD).Methods Logistic regression were used to analyze the associativity of K-F ring grades and clinical materials,chemical indices of 116 WD cases using SPSS 19.0 software.Results The total positive rates of K-F ring were 90.5％ in 116 WD cases.Among them,cerebral-type patients were 96.8％,liver-type patients were 75％,presymptom-type patients were 66.7％.Logistic regression analysis showed that there was positive correlation between grades of K-F ring and clinical severity(P ＜ 0.05),but there were no relation with course,clinical types,Sco,CP,liver function and other indicators (P ＞ 0.05).Conclusion The K-F ring may be a relatively independent clinical signs in WD,its grades can be used as one of the indicators to judge the clinical severity.%目的 探讨Wilson病(Wilson's disease,WD)角膜Kayser-Fleischer(K-F)环临床特点及相关因素.方法 对116例WD患者K-F环进行量化分级,运用SPSS19.0软件进行Logistic回归分析探讨K-F环分级与临床资料、生化指标的相关性.结果 116例WD患者K-F环总阳性率90.5％,其中脑型阳性率最高(96.8％),其次肝型阳性率75％,症状前型阳性率66.7％.K-F环分级大小与临床严重程度呈正相关(P＜0.05)；与病程、临床类型、Sco、CP、肝功能等指标无相关性(P＞0.05).结论 K-F环可能是WD一个相对独立的临床体征,其分级大小可作为WD病情严重程度判断的指标之一.