钙离子稳态失调与癌症增殖转移关系的研究进展

摘要

自1944年Carruthers和Suntzeff第1次描述了钙离子与癌症之间的关系以来,钙离子稳态失调就被认为与肿瘤的发生发展有着必然的联系.近年来越来越多的研究发现无论是细胞增殖或转移都与钙离子失衡关系密切,而钙离子调控机制的异常是钙离子失调的主要诱因.对钙离子失调的可能原因和其与癌症增殖转移间的关系进行综述.%Calcium homeostasis has been thought to be associated with tumor development since Carruthers and Suntzeff first described the relationship between calcium and cancer in 1944.Recently more and more studies have found that both cell proliferation and metastasis are related to calcium homeostasis closely,and the abnormality of Ca2+ regulation mechanism is the main cause of calcium homeostasis.This article aims to review the possible cause of calcium homeostasis and its relationship with cancer proliferation and metastasis.