Objective To evaluate the efficacy and safety of combined treatment of discolored teeth by two tooth whitening agents with different hydrogen peroxide concentrations .Methods 66 patients with discolored teeth accept-ed combined bleaching treatment by two tooth whitening agents with different hydrogen peroxide concentrations ( typeⅠ35%and typeⅡ35%) .Vita shade guide was used to record pre and post-bleaching color gradation .Observation of adverse reactions was also conducted .Results Compared with pre-treatment state ,post-treatment color gradation was 5 .9 higher on the average .Differences in color gradation before and after treatment were statistically significant ( P<0 .000 1 ) .The treatment showed a significant whitening effect in patients with exogenously stained teeth , naturally yellow teeth and mildly fluorotic teeth .Whitening effect on tetracycline stained teeth was detected but not ideal .No se-rious adverse reaction was observed .Conclusion As per statistic data of clinical experimental results , combined treatment by two tooth whitening agents containing different concentrations of hydrogen peroxide is effective and safe for teeth whitening .%目的：探讨两种浓度过氧化氢牙齿美白剂联合治疗变色牙的效果与安全性。方法对66例变色牙患者进行两种浓度过氧化氢牙齿美白剂联合漂白治疗（Ⅰ型35％、Ⅱ型6％），并用Vita比色板比色记录漂白前后的色阶，同时观察治疗期间的不良反应。结果治疗后的色阶平均提高了5．9个，明显高于治疗前，差别有统计学意义（P＜0．0001）；对外源性染色牙、天然色黄及轻度氟斑牙的患者美白效果显著，而四环素牙的患者美白有效，但不理想；所有患者均未出现严重不良反应。结论两种浓度牙齿美白剂型联合治疗变色牙的美白效果显著且安全。
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