Up-regulation of Human Leukocyte Antigen G Expression in Primary Cutaneous Malignant Melanoma Associated with Host-vs-tumor Immune Response

摘要

Human leukocyte antigen G(HLA-G) is one of the molecules implicated in immunotol-erance.To investigate the role of HLA-G in primary cutaneous malignant melanoma(CMM),a series of 47 skin melanocytic lesions were immunohistochemically evaluated.The correlation between HLA-G expression and CMM clinicohistopahtological data and Bcl-2 expression was also analyzed.HLA-G expression was detected ina variety of cell types.No significant difference in HLA-G ex-pression was observed between malignant and non-malignant melanocytic lesions.HLA-G expres-sion was significantly correlated with the inflammatory infiltration and Bcl-2 expression,whereas no significant correlation with ulceration,tumor thickness,clinical stage,histopathological subtypes were observed.HLA-G expression may be the result of host immune reaction in tumor microenvi-ronment rather than a malignant feature of CMM.