NB-UVB、曲安奈德、白癜风颗粒三联疗法治疗后白癜风患者外周血及皮损组织中病情相关指标的评估

摘要

目的：：研究 NB-UVB、曲安奈德、白癜风颗粒三联疗法治疗后白癜风患者外周血及皮损组织中病情相关指标的变化情况。方法：选择白癜风患者作为研究对象并随机分为两组,观察组接受 NB-UVB、曲安奈德、白癜风颗粒三联疗法治疗,对照组接受 NB-UVB、曲安奈德二联疗法治疗,检测外周血中淋巴细胞亚群、细胞因子的含量以及皮损组织中病情相关分子的表达量。结果：治疗后,观察组外周血中CD3+ CD28+、CD3+ CD4+ CD28+、CD3+ CD8+ CD28+、Th17细胞的百分比以及 IL-17、IL-6的含量低于对照组,CD3+ CTLA4+、CD3+ CD4+ CTLA4+、CD3+ CD8+ CTLA4+、Treg 细胞的百分比以及 IL-10、TGF-β的含量明显高于对照组；观察组皮损组织中 Nrf-2、SCF、c-kit、InnVit 的表达量高于对照组, CLEC2B 的表达量低于对照组。结论：NB-UVB、曲安奈德、白癜风颗粒三联疗法治疗能够更为有效的调节白癜风患者的免疫功能以及皮损组织中病情相关分子的表达。%[ABSTRACT]Objective:To study the changes of illness-related indicators in peripheral blood and skin lesion tissue of pa-tients with vitiligo after NB-UVB,triamcinolone acetonide and vitiligo granules triple treatment.Methods:Patients with vitili-go were selected as research subjects and randomly divided into two groups,and observation group received NB-UVB,triamci-nolone acetonide and vitiligo granules triple treatment,control group received combined therapy of NB-UVB and triamcinolone acetonide.The contents of lymphocyte subsets and cytokines in peripheral blood as well as the expression of illness-related molecules in skin lesion tissue were detected.Results:After treatment,the percentage of CD3 + CD28 + ,CD3 + CD4 + CD28 + , CD3 + CD8 + CD28 + and Th1 7cells as well as the contents of IL-1 7 and IL-6 in peripheral blood of observation group were signif-icantly lower than those of control group,while the percentage of CD3 + CTLA4 + ,CD3 + CD4 + CTLA4 + ,CD3 + CD8 + CT-LA4 + and Treg cells as well as the contents of IL-10 and TGF-βwere significantly higher than those of control group;the ex-pression levels of Nrf-2,SCF,c-kit and InnVit in skin lesion tissue of observation group were higher than those of control group,while CLEC2B expression level was lower than that of control group.Conclusion:NB-UVB,triamcinolone acetonide and vitiligo granules triple treatment can more effectively regulate immune function and expression of illness-related molecules in skin lesion tissue of patients with vitiligo.