食品有害物苯并(α)芘及其诱导细胞死亡的研究进展

摘要

Benzo-a-pyrene (BaP) is a kind of common harmful substances which is produced during the processing of plant oil.BaP has attracted significant attention due to its carcinogenicity,teratogenesis and widely distributing.The injurious effects of BaP on cells are reviewed in this paper.BaP can cause body tissue damage through inducing DNA damage,mitochondrial dysfunction,oxidative stress,autophagy and inflammatory response.Pyroptosis is a way of cell death which is dependent on the caspase-1 with the release of inflammatory factors.However,the effect of BaP on pyroptosis remains unknown.To further reveal the cytotoxicity mechanisms of BaP has an important scientific significance to the targeted intervention and the establishment of comprehensive and effective food safety control system.%苯并(α)芘(Benzo-a-pyrene,BaP)是一种常见的油脂加工过程中产生的主要有害产物,由于其致癌、致畸、广分布的特点,近年来备受学者关注.作者综述了近些年国内外对BaP损伤机体细胞的作用机制,总结为其主要通过诱导细胞DNA损伤、线粒体功能障碍、氧化应激、自噬性损伤及炎症反应损害机体损伤.细胞焦亡是一种依赖半胱天冬酶-1并伴有大量炎症因子释放的细胞死亡方式.但苯并(α)芘对细胞焦亡作用的影响还不确定,有待进一步研究论证.深入揭示食品有害物质苯并(α)芘的毒性机制对其危害干预和构建全面有效的食品安全控制体系具有重要意义.