利巴韦林在畜禽体内的代谢规律与检测技术研究进展

摘要

Ribavirin is a kind of artificial synthetic of nucleoside broad-spectrum antiviral drugs andit is widely used in clinical medicine.However, because of the interests of illegal, the phenomenon of abuse of ribavirin still exists in the process of livestock and poultry breeding, and it is forbidden due to occur repeatedly the poison of livestock and poultry ribavirin in production practice. The present paper mainly introduced the research status of ribavirin target and detection technique in animal body. The basic physicochemical properties, synthetic method and pharmacokinetics of ribavirin drugs were described, the domestic and foreign current detecting standards and methods of ribavirin were summarized, and the advantages and disadvantages of each kind of drugs detection method were analyzed and evaluated. It could provide references for food safety workers and researchers, and lay a good foundation to the rapid development of meat industry and the safeguard of people’s safety.%利巴韦林是一种人工合成的核苷类广谱强效抗病毒药物，主要用于临床医学，在畜禽养殖过程因利益驱使违规使用利巴韦林药物的现象仍普遍存在，导致在生产实践中多次发生畜禽利巴韦林中毒事件而被禁止使用。本文主要介绍了利巴韦林在畜禽动物体内的代谢规律及检测方法的研究现状。重点阐述了利巴韦林药物的基本理化性质、合成方法及药代动力学；并归纳总结了我国现行有效的该药物残留标准检测方法及其他新型检测方法，详细分析和评价每种检测方法的优缺点。旨在为食品安全工作者及科研人员提供参考，为肉食品行业健康快速发展和保障人们食品安全奠定基础。