红肉中N-羟乙酰神经氨酸解离方法的研究进展

摘要

Accumulating immunogenic N-glycolylneuraminic acid (Neu5Gc) in human bodies though consumption of red meat has potential carcinogenicity, which derives the issue of red meat safety to a higher level concerning. Getting rid of Neu5Gc from red meat and exploring the dissociation mechanism before and after slaughter are imperative. This paper simply introduced the source and structure of Neu5Gc, revealed the potential carcinogenicity hazard of Neu5Gc to human bodies accoding to the reseaches on Neu5Gc of foreign scholars, and summed up the dissociation methods about Neu5Gc at home and abroad. The feasibilities of molecular simulation to predict the bond dissociation energy of Neu5Gc and collect Neu5Gc dynamic variation trend in red meat were also discussed. This manuscript aims to provide theoretical support for exploring effective dissociation methods of Neu5Gc and show its research value in meat study.%免疫原性的N-羟乙酰神经氨酸(N-glycolylneuraminic acid, Neu5Gc)属于致癌的高风险物质,人体中的Neu5Gc主要是通过红肉的摄入而在人体内积累,因此, N-羟乙酰神经氨酸的致癌性又将红肉的安全隐患问题推上了新的高度,探索屠宰前后Neu5Gc安全稳妥的解离方法以及解离机制势在必行。本文简要介绍了Neu5Gc的来源及其结构,通过国外学者对Neu5Gc的研究,揭示了Neu5Gc对人体潜在的致癌性危害,总结了国内外关于 Neu5Gc 解离方法的研究现状,并对采用分子模拟方法精准预测 Neu5Gc 的键解离能并获取红肉中 Neu5Gc的动力学变化信息研究的可行性进行了讨论。本研究旨在为肉类研究及其生产领域探索促进非人源 Neu5Gc解离的方法提供理论支撑,并充分展示其在肉类研究领域的研究价值。