姜黄葛根白芍片对去卵巢大鼠模型骨密度的影响研究

摘要

目的：研究姜黄葛根白芍片对去卵巢大鼠模型骨密度的影响,探讨其增加骨密度的作用。方法采用去卵巢的方法建立大鼠骨质疏松模型,用不同浓度的姜黄葛根白芍片灌胃剂量组动物,12周后检测其骨密度、股骨恒重和骨钙含量,观察骨组织病理形态,评价其增加骨密度的作用。结果与模型组对比,姜黄葛根白芍片低、中、高剂量组大鼠的骨密度和股骨恒重均显著增加,中、高剂量组的骨钙含量显著高于模型组,各剂量组骨组织的病理组织学指标与模型组相比有显著性改善。结论姜黄葛根白芍片具有增加大鼠骨密度和骨钙含量的作用,并且能够改善骨组织的病理形态,对治疗临床绝经后骨质疏松症有一定作用。%Objective To investigate the effect of turmeric-pueraria-paeoniae radix tablet on bone mineral density in ovariectomized rats, and discuss the function for increasing bone mineral density.MethodsThe osteoporosis model was established by removing the ovaries in experimental rats. The rats of dose groups were treated with different concentrations of turmeric-pueraria-paeoniae radix tablet through intragastric administration. After 12 weeks, the bone mineral density (BMD), constant weight of femur and calcium content (BCC) of bone were detected, and the observation of pathological morphology of bone tissue was conducted simultaneously, based on which the function for increasing bone mineral density of the tablet was evaluated.ResultsCompared with model group, the levels of bone mineral density and constant weight of femur in rats of low, medium and high dose groups were all increased significantly, and the BCC in rats of medium and high dose groups were higher than that of model group. The histopathological indexes of bone tissue had significant improvement in rats of 3 dose groups.Conclusion Urmeric-pueraria-paeoniae radix tablet has the function of enhancing BMD and BCC in rats, and it can improve the pathological morphology of bone tissue, which has an effect on the treatment of clinical postmenopausal osteoporosis.