吸烟对不同性别AECOPD患者气道炎症影响

摘要

目的 通过比较不同性别COPD急性发作期(AECOPD)患者的肺功能、血清细胞因子差异,研究性别差异对COPD患者气道炎症的影响.方法 将AECOPD患者分为四组,其中1组为既往无吸烟史男性,2组为吸烟指数>200支年男性,3组为既往无吸烟史女性,4组为吸烟指数>200支年女性,每组25例.检测所有患者入院时肺功能、血浆IL-8、TNF-α值.结果 非吸烟男性和女性血清炎症因子IL-8、TNF-α和肺功能比较无显著性差异(P>0.05),而在长期吸烟患者中,男性和女性患者的炎症因子、肺功能与无吸烟男性和女性比较均有显著性差异(P<0.05),同时吸烟女性与吸烟男性比较炎症因子更高(P<0.05)和肺功能更差(P<0.05).结论 吸烟的COPD女性患者在急性发作期炎症因子释放高于不吸烟女性及吸烟男性.%Objective To explore the effect of gender difference on airway inflammation by comparing lung function and serum cytokine in different gender of patients with acute exacerbation of COPD. Methods AECOPD patients were divided into four groups, including group I male without past history of smoking, group II male of smoking index >200, group III female without past history of smoking, and group IV female of smoking index >200,each group with 25 cases. Lung function, and plasma IL-8 ,TNF-α level were tested on admission in all patients. Results Comparing between non-smoking male and female in lung function, and plasma IL-8 ,TNF-a level, there were no significant differences( P >0. 05 ). While in the long-term smoking patients, there were significant differences( P <0. 05 ) compared between smoking male and non-smoking male, and smoking female and non-smoking female in lung function, and plasma IL-8, TNF-α level. Meanwhile, smoking female had higher plasma IL-8 ,TNF-α level and worse lung function than smoking male,with significant differences( P <0. 05 ). Conclusions The level of inflammatory cytokines in smoking female with AECOPD are higher than those in nonsmoking female and smoking male.