hs-CRP、Fib、NT-proBNP在COPD合并肺动脉高压中的研究及意义

摘要

目的：观察C反应蛋白( hs-CRP)、纤维蛋白原( Fib)、N-端脑钠肽前体( NT-proBNP)在慢性阻塞性肺病( COPD)合并肺动脉高压患者血液中的变化,分析相关性及意义。方法选取我院COPD患者105例,分A组(单纯COPD组,55人)、B组( COPD合并肺动脉高压组,50人)。行肺功能、心脏彩超检查,检测hs-CRP、NT-proBNP、Fib及血气分析。结果 hs-CRP、Fib、NT-proBNP 在 B 组均高于 A 组(均 P <0．05)；PaCO2、hs-CRP、Fib 、NT-proBNP 水平与肺动脉压呈正相关；PaCO2、hs-CRP、Fib与NT-proBNP呈正相关。结论hs-CRP、Fib、NT-proBNP参与了COPD合并肺动脉高压的形成,全身炎症在COPD继发肺动脉高压的发病中发挥重要作用。%Objective To observe the changes of hypersensitive C-reactive protein (hs-CRP), Fibrinogen ( Fib) , N-terminal fragment of pro-brain natriuretic peptide ( NT-proBNP) in COPD patients complicated with pulmo-nary hypertension ( PH) . Methods 105 patients with COPD were enrolled in our hospital. 55 patients were classi-fied as the group A ( COPD without PH) and 50 patients as the group B ( COPD with PH) . Pulmonary pressure was assessed by Doppler echocardiography, FEV1% and FEV1/FVC by lung function test. The expression of hs-CRP, NT-proBNP and Fib and arterial blood gas analysis were measured. Results The levels of hs-CRP, Fib and NT-proBNP in the group B were significantly higher than in the group A (P<0. 05). The levels of PaCO2, hs-CRP, Fib and NT-proBNP were positively correlated with pulmonary pressure ( P<0. 05 ) . The levels of PaCO2 , hs-CRP and Fib were positively correlated with NT-proBNP (P<0. 05). Conclusion The levels of hs-CRP, Fib, NT-proBNP are positively related to PH in COPD patients, suggesting that systemic inflammation plays a role in the pathogenesis of PH in COPD.