目的：探索鼠神经生长因子（mNGF）对手足口病（HFMD）合并中枢神经系统损伤患儿神经功能的修复作用。方法按照住院号的单双数，将本院收治的86例重症 HFMD 患儿分为治疗组和对照组，每组43例。2组均接受 HFMD 常规综合治疗，治疗组在此基础上肌注 mNGF。比较2组神经系统损伤相关症状的消失时间，评价治疗前及治疗3、7 d 时神经功能评分及治疗前后白细胞及肌酸激酶水平，并观察不良反应的发生情况。结果治疗组呕吐、易惊、肢体抖动、肌无力和嗜睡的消失时间及住院时间显著短于对照组，差异均有统计学意义；治疗3、7 d 时，2组神经功能评分均较治疗前显著降低，且治疗组显著低于对照组；2组治疗后白细胞及肌酸激酶水平均较治疗前明显降低，且治疗组下降幅度更大。2组治疗期间肝肾功能检查均未发现明显异常。结论对于 HFMD 合并中枢神经系统损伤的患儿，给予 mNGF 可有效促进受损神经组织的修复，改善神经功能，缩短病程。%Objective To explore the repair effect of mouse nerve growth factor (mNGF) on the neurological function of hand-foot-and-mouth disease (HFMD)children with central lesion. Methods 86 children with severe HFMD were divided into treatment group and control group ac-cording to the number of hospitalization,43 cases in each group.Both groups were treated with conventional comprehensive treatment for HFMD,while the treatment group was injected with mNGF on the basis of basic treatment.The disappearance time of symptoms associated with nervous system injury,neurological scores before treatment and on the third,seventh days of treatment as well as the levels of while cells and creatine kinase (CK)before and after treatment were compared, and the adverse reactions were observed.Results The disappearance time of vomiting,skittishness, limb shaking,myasthenia and somnolence as well as hospital stay in the treatment group were sig-nificantly shorter than those in the control group.Neurological scores on the third,seventh days of treatment decreased significantly in both groups,and neurological scores in treatment group were significantly lower than control group.After treatment,the levels of white cells and CK decreased significantly in both groups,and the decreased range in treatment group was larger.No obvious ab-normal reactions were observed by liver and kidney examination during treatment.Conclusion For children with HFMD and central lesion,application of mNGFcan effectively promote the repairmen of injured nervous tissue,improve the neurological function and shorten the course of disease.
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