血清瘦素、胱抑素C和人绒毛膜促性腺激素在妊娠高血压综合征检测中的意义

摘要

目的：观察血清瘦素、胱抑素 C（CysC）和人绒毛膜促性腺激素（β- HCG）在妊娠高血压综合征检测中的意义。方法选取2011年1月至2014年6月收治的妊娠高血压患者150例为妊高症组；同期正常妊娠的患者60例为正常妊娠组；另选同期健康非妊娠妇女30例为健康对照组。观察健康对照组，正常妊娠组和妊高症组的瘦素、CysC 和β- HCG 水平，与妊高症严重程度的关系，各指标之间的相互关系。结果正常妊娠组和妊高症组的瘦素、CysC 和β-HCG 水平明显高于健康对照组（ P ﹤0.01），而妊高症组明显高于正常妊娠组（ P ﹤0.01）。随着妊高症病情严重程度的增加，瘦素，CysC 和β- HCG 水平出现明显的增高（ P ﹤0.01）。妊高症患者瘦素水平与 CysC（ r =0.673，P ﹤0.01）和β- HCG（ r =0.838，P ﹤0.01）水平呈正相关，CysC 与β- HCG（ r =0.792，P ﹤0.01）水平呈正相关。结论检测瘦素、CysC 和β- HCG 水平有助于对妊娠高血压患者的诊断和分级，其异常升高应引起临床的高度重视。%Objective To observe the clinical significance of serum leptin,cystatin C(CysC)and human chorionic gonadotropin(β -HCG)in patients with pregnancy - induced hypertension. Methods A total of 150 patients with pregnancy - induced hypertension during January 2011 to June 2014 were selected as pregnancy - induced hypertension group;60 patients with normal pregnancy at the same period were allocated in normal pregnancy group,and 30 healthy women without pregnancy were selected as healthy control group. Levels of leptin,CysC and β - HCG were examined among pregnancy - induced hypertension group,normal pregnancy group and healthy control group,the relationship among levels of leptin,CysC and β - HCG and the severity of patients with pregnancy - induced hypertension were observed,the correlation between each marker had been evaluated. Results Levels of leptin,CysC and β - HCG in women with normal pregnancy and patients with pregnancy - induced hyper-tension were significantly higher than those of control group( P ﹤ 0. 01),and their levels in pregnancy - induced hypertension group were signifi-cantly higher than those of normal pregnancy group( P ﹤ 0. 01). The levels of leptin,CysC and β - HCG were significantly elevated as the in-crease of severity of pregnancy - induced hypertension( P ﹤ 0. 01). The level of leptin in patients with pregnancy - induced hypertension was positively correlated with the levels of CysC( r = 0. 673,P ﹤ 0. 01)and β - HCG( r = 0. 838,P ﹤ 0. 01),there was also positive correlation between levels of CysC and β - HCG( r = 0. 792,P ﹤ 0. 01). Conclusion The detection of levels of leptin,CysC and β - HCG is helpful in diagnosis and classification of patients with pregnancy - induced hypertension,their abnormal elevation should lead physicians to pay more attention to these patients.