补肾益气扶正汤辅助治疗肾癌患者术后应用重组人干扰素α2b 产生的不良反应疗效观察

摘要

Objective To evaluate the role of Bushen Yiqifuzheng tang in treatment of adverse effects of recombinant human interferonα2b in postoperative patients with renal cancer. Methods Ninety - six patients with renal cancer treated in this hospital during January 2010 to February 2015 were involved in this present study. These patients were randomly divided into experimental group and control group. Patients in control group and experimental group received the treatment of recombinant human interferon α2b for 14 days after operation,and patients in exper-imental group were simultaneously received Bushen Yiqi Fuzheng tang for supplementary treatment. The general conditions of patients and adverse reactions were evaluated during the 3 - month follow - up period. Results After treatment for three months,the general condition of patients in experimental group was significantly better than that of patients in control group. Patients in experimental group got benefits on less flu - like symp-toms,less digestive symptoms,less neuropsychiatric symptoms and less reduction of blood cells,and the difference between these two groups was statistically significant( P < 0. 05). Conclusion The application of Bushen Yiqifuzheng tang can improve the general condition of patients with renal cancer received post - operative recombinant human interferon α2b by reducing flu - like symptoms,digestive symptoms,neuropsychiatric symptoms and reduction of blood cells,thus it suggests its potential for clinical application.%目的：探讨中药补肾益气扶正汤辅助治疗肾癌患者术后应用重组人干扰素α2b 产生的不良反应的临床疗效。方法随机选取2010年1月至2015年2月住院治疗的肾癌患者96例，并将其随机平均分成实验组和对照组，对照组患者在手术后的第14天开始给予重组人干扰素α2b 免疫治疗，而实验组在对照组的基础上再口服自拟中药补肾益气扶正汤辅助治疗，3个月后对比两组患者的患者全身状况、病情变化情况以及不良反应发生情况。结果治疗后，实验组患者的行为状况要明显优于对照组，流感样及消化道、神经精神系统症状、血细胞减少等相关不良反应发生率明显低于对照组，差异有统计学意义（ P <0.05）。结论肾癌患者应用重组人干扰素α2b +补肾益气扶正汤联合治疗能够很好地改善患者的全身状况，降低相关不良反应的发生率，具有明显临床治疗效果，值得在临床工作中应用。