左乙拉西坦治疗中老年癫痫患者的临床疗效及其对骨密度的影响

摘要

Objective To explore the clinical efficacy of levetiracetan in treatment of elderly patients with epilepsy and its impact on bone mineral density.Methods A total of 67 cases of epilepsy were collected.The application of levetiracetam tablets for treatment and evaluation of its efficacy had been undertaken.The changes of bone mineral density and bone metabolism in 6 months after treatment and before treatment were compared and analyzed.Results Patients with various types of seizure of epilepsy had received better treatment,with efficacy of 66.7％ to 95.0％.After treatment for 6 months,BMD in L2-4,Ward triangle,femoral neck and trochanter showed slightly decreased in comparison with those before treatment,but the difference was not significant.There was no significant difference in blood levels of calcium,phosphorus,alkaline phosphatase and parathyroid hormone in patients with epilepsy before treatment and 6 months after treatment.Conclusion The application of levetiracetam in treatment of patients with various types of seizure has better effect on mineral density of bones in patients with epilepsy,without significant adverse effects,hence it is worthy to be clinically applied.%目的 探讨左乙拉西坦治疗中老年癫痫患者的临床疗效及其对骨密度的影响.方法 选择癫痫患者共67例,采用左乙拉西坦片单药治疗,评价治疗效果,并比较治疗后6个月与治疗前相比骨密度和骨代谢的变化.结果 左乙拉西坦单药治疗6个月后,各种发作类型的癫痫患者均获得了较好的治疗效果,有效率66.7％ ～95.0％.治疗后6个月癫痫患者L2-、Ward三角区、股骨颈和股骨大转子的骨密度与治疗前相比均略有降低,但差异均无统计学意义(P＞0.05).癫痫患者的血钙、磷、碱性磷酸酶、甲状旁腺素在治疗前和治疗后6个月比较,差异无统计学意义(P＞0.05).结论 左乙拉西坦单药治疗对各个发作类型癫痫疗效较好,对癫痫患者骨密度、骨代谢无明显不良影响,值得临床应用.