Objective To investigate the clinical effect of Buyang Huanwu decoction combined with Epalrestat in the treatment of type 2 diabetic peripheral neuropathy. Methods 72 cases with type 2 diabetic peripheral neuropathy from diabetes department of our hospital were selected and randomly divided into 2 groups, 36 cases each. The control group received epalrestat treatment, and the study group received more with Buyang Huanwu decoction, 2 groups were treated for 4 weeks. Clinical indexes, blood serum index , and adverse reaction condition were compared after the treatment. Results Compared with the control group, the motor nerve and sensory nerve conduction velocity in the study group were higher, scores of pain, burning sensation, paresthesia and numbness were lower, levels of serum CRP, 8-iso-PGF2α and TNF-α and IL-6 were lower, levels of T-AOC and MDA were lower, and levels of SOD were higher (P<0.05), there were no patients were followed off phenomenon, there were no differences in adverse rate comparison (P>0.05). Conclusion Buyang Huanwu decoction combined with epalrestat in the treatment of type 2 diabetic peripheral neuropathy was effective, and the mechanism may reduce the inflammatory factor, improve the ability of antioxidation.%目的 探讨补阳还五汤加减联合依帕司他治疗2型糖尿病周围神经病变的临床疗效.方法 研究对象为我院糖尿病科符合纳入标准且确诊为2型糖尿病周围神经病变患者72例,按随机数字表法分为2组,各36例,对照组予以依帕司他治疗,研究组予以补阳还五汤加减联合依帕司他治疗,均4周为1疗程,观测临床相应指标,采血测定血清学指标,同时对比不良反应情况.结果 治疗后与对照组比较,研究运动神经传导速度和感觉神经传导速度较高,疼痛、灼热感、感觉异常、麻木及总分较低,CRP、8-iso-PGF2α、TNF-α 及IL-6水平较低,T-AOC、MDA水平较低,SOD水平较高(P<0.05);所有患者均获得随访,无病例脱落现象,不良率对比无统计学意义(P>0.05).结论 补阳还五汤加减联合依帕司他治疗2型糖尿病周围神经病变疗效确切,推测其机制与降低炎症因子,提高抗氧化能力有关.
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