use of a therapeutic combination, pharmaceutical formulation, article of manufacture, product, method for determining compounds to be used in combination for the treatment of a hematopoietic malignancy and method for selecting compounds to be used in combination for the treatment of cancer

摘要

use of a therapeutic combination, pharmaceutical formulation, article of manufacture, product, method for determining compounds to be used in combination for the treatment of hematopoietic malignancy and method for selecting compounds to be used in combination for the treatment of cancer the present invention relates to combinations of pi3k inhibitor compounds that have formula ie chemotherapeutic agents, including stereoisomers, geometrical isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, which are useful for the treatment of hematopoietic malignancies. the present invention also relates to methods for using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions.