依托红霉素对哮喘患儿血清 IL－8、MMP－9、TIMP－1的影响

摘要

Objective To investigate the effect of erythromycin estolate of serum matrix metalloproteinase -9(MMP-9),matrix metalloproteinase inhibitor-1(TIMP-1) and interleukin -8(IL-8) in treatment of bronchial asthma (asthma) in children.Methods One hundred children with asthma were randomly divided into control group and erythromycin group with 50 cases in each group and were given the global initiative for asthma (GINA) scheme for regular treatment and erythromycin estolate group was given additional e -rythromycin for treatment of 4 weeks.The serum levels of IL-8,MMP-9,TIMP-1 change of the two groups before and after treatment were compared.Results The serum levels of IL-8,MMP-9,TIMP-1 of the two groups were decreased after treatment ( P <0.01), with that of the erythromycin estolate group decreased more significantly than that of the control group ( P <0.01).Conclusion E-rythromycin estolate treatment on the basis of conventional GINA can help to reduce the serum levels of IL -8,MMP-9 and TIMP-1 in children with asthma.%目的：探讨依托红霉素对支气管哮喘（简称哮喘）患儿血清白细胞介素－8（IL－8）、基质金属蛋白酶－9（MMP－9）、基质金属蛋白酶抑制剂－1（TIMP－1）的影响。方法将100例哮喘患儿随机分为对照组与观察组，各50例，均给予全球哮喘防治创议（GINA）方案正规治疗；观察组加用依托红霉素治疗4周。比较两组治疗前后血清 IL－8、MMP－9、TIMP－1变化。结果两组血清 IL－8、MMP－9、TIMP－1治疗后较治疗前均下降（ P ＜0．01），观察组较对照组下降更为明显（ P ＜0．01）。结论儿童哮喘在常规 GINA 方案治疗基础上给予依托红霉素治疗有利于促使血清 IL－8、MMP－9、TIMP－1水平降低。