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VARIATION IN THE CHI3L1 GENE INFLUENCES SERUM YKL-40 LEVELS, ASTHMA RISK, AND LUNG FUNCTION
VARIATION IN THE CHI3L1 GENE INFLUENCES SERUM YKL-40 LEVELS, ASTHMA RISK, AND LUNG FUNCTION
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机译:CHI3L1基因的变化影响血清YKL-40水平,哮喘风险和肺功能
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摘要
The present invention is based on the discovery that a single nucleotide polymorphism (SNP) present the chitinase 3-like 1 gene (CHI3L1) encoding YKL-40 or a regulatory domain of the CHI3L1 gene, is associated with elevated YKL-40 levels, as well as an increased risk for developing a lung disorder, including asthma, bronchial hyperresponsivity, and/or reduced lung function.
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