中药配合低剂量化疗药物经肝动脉化疗栓塞术治疗中晚期肝癌的临床观察

摘要

目的：探讨中药配合低剂量化疗药物经肝动脉化疗栓塞术（TACE）治疗中晚期原发性肝癌的临床疗效和毒副反应。方法中晚期肝癌患者57例随机分为治疗组（29例）和对照组（28例）。治疗组给予中药联合低剂量化疗药物TACE，对照组仅给予常规剂量化疗药物TACE。比较观察2组的临床疗效和毒副反应。结果2组瘤体有效率比较差异无统计学意义（P﹥0.05）；2组患者中医证候改善的疗效比较差异有统计学意义（P﹤0.05）；2组AFP控制有效率比较差异有统计学意义（P﹤0.05）；2组在肝肾功能及白细胞变化方面比较差异有统计学意义（P﹤0.05）；2组恶心呕吐、乏力、肝区疼痛发生率比较均有统计学意义（P均﹤0.05）；2组患者整体生活质量比较差异有统计学意义（P﹤0.05）。结论中药配合低剂量化疗药物TACE治疗中晚期肝癌能明显较单纯TACE提高患者生活质量及对治疗的耐受性。%Objective To investigate the clinical effect and toxicities of transcatheter arterial chemoembolization ( TACE)with low-dose chemotherapy drugs combined with traditional Chinese drug for advanced liver cancer. Methods Fifty-seven patients with advanced liver cancer were divided into the two groups,29 patients of the treat-ment group received the TACE with low-dose chemotherapy drugs combined with traditional Chinese drug,28 pa-tients of the control group received the TACE with normal-dose chemotherapy drugs,and the efficacy and toxicities were observed. Results There was no statistical difference in the effectiveness rate of tumor size between the two groups(P﹤0. 05). There were statistical differences in the effectiveness rate of syndromes of TCM between the two groups(P﹤0. 05). There were statistical differences in the AFP control rate between the two groups(P﹤0. 05). There were statistical differences in the liver function,renal function and leucocyte counts between the two groups (P﹤0. 05). There were statistical differences in the nausea and vomitting,anergy and hepatalgia between the two groups(P﹤0. 05). There were statistical differences in the quality of life between the two groups(P﹤0. 05). Con-clusion Compared with pure TACE method,TACE with low-dose chemotherapy drugs combined with traditional Chinese drug can improve the quality of life and the tolerance.