胆道梗阻病人胆汁中肿瘤标志物的变化及临床意义

摘要

目的 探讨胆汁癌胚抗原(CEA)、CA19-9、CAl25检测在胆道梗阻病人中的临床意义.方法 选择经手术或(和)病理检查证实的胆道恶性病变致胆道梗阻32例(胆道恶性病变组),与同期胆道良性病变致胆道梗阻36例(胆道良性病变组),分别检测其血清和胆汁中的CEA、CA19-9、CA125含量,并对其进行分析比较.结果 胆道恶性病变组病人胆汁中CEA、CA19-9、CAl25的含量与其在血清中的含量比较,差异均有统计学意义(P<0.01).而胆道良性病变组胆汁中CEA、CA19-9、CA125含量与血清中检测结果 比较,差异均没有统计学意义(P>0.05).结论 胆汁中CEA、CAl9-9、CAl25测定对于胆道良、恶性病变所致胆道梗阻的鉴别有一定的临床意义.%Objective To explore the preoperative diagnostic values of carcinoembryonic antigen (CEA) ,CA19-9,CA125 in bile. Methods Thirty-two cases of malignant biliary obstruction as experimental groups and 36 cases of benign biliary obstruction as control group were selected. The levels of CEA,CA19-9 and CA125 in serum and bile were detected and compared. Results The levels of CEA,CA19-9 and CA125 in bile were significantly higher than those in serum in experimental group(P＜0. 01). The levels of CEA,CA1 9-9 and CA125 in bile and serum had no statistically significant difference in control group(P＞0. 05). Conclusion The determination of CEA,CA19-9 and CA125 in bile has significant values in preoperative differential diagnosis between the malignant biliary straitness and the benign biliary straitness.