Objective To explore the ADC values and rADC of normal adult clivus marrow with 3.0T MR scanner.Methods Multi-b-value DWI was performed in 61 healthy volunteers with Philips Achieva 3.0T TX MR scanner and SENSE NeuroVascular 16 coil.Following the images were transferred to dedicated workstation,image quality were graded and the ADC values of clivus and brain stem were calculated with a junior and a senior radiologist respectively.One month later,the second ADC measurements were done by the senior radiologist. rADC was calculated by ADCclivus/ADCbrain stem.The CV were calculated to valuate the reproducibility of the measurements of ADCbrain stem,and the ICC to valuate the agreement between the intra-observer and inter-observer.Results There were 58 cases enrolled in our study. The ADCclivus were ranged between 0.14×10-3 mm2/s to 0.15×10-3 mm2/s and rADC between 0.204 to 0.219,there were no significant differences in ADCclivus and rADC between the intra-observer and inter-observer.The ICC of ADCclivus with the intra-observer and inter-observer were 0.938 and 0.965.The CV of ADCbrain stem of the junior and first and second measurements of the senior radiologist were 0.0964±0.0190,0.0832±0.0130,0.0903±0.0173,re spectively.Conclusion There are good agreement of ADCclivus,rADC and ADCbrain stem between the intra-observer and inter-observer.There are excellent reproducibility of the measurements of ADCbrain stem,brain stem could potentially be used as an internal reference parameter.%目的：初步探讨正常成人斜坡骨髓3.0 T磁共振多b值DWI的ADC值与rADC。方法：采用Philips 3.0 T TX Achieva磁共振成像仪、16通道头颈神经血管线圈，对61例健康志愿者行多b值DWI扫描。利用随机工作站的diffusion软件包对原始数据进行后处理，获取ADC图，先由1名低年资、1名高年资影像医生分别对图像进行质量分级，再对入列的58例进行双盲测量斜坡骨髓、脑干ADC值，1个月后，高年资医生进行第2次测量，并以脑干ADC值作为参照，计算斜坡骨髓rADC，将所得数据进行统计学分析。结果：观察者间、观察者内测量的斜坡骨髓ADC值、rADC差异无统计学意义（P＞0.05），斜坡骨髓ADC值在观察者间、观察者内的ICC为0.938、0.965。脑干ADC值的CV：低年资者为（0.0964±0.0190）、高年资者第1次为（0.0832±0.0130）、高年资者第2次为（0.0903±0.0173），在观察者间、观察者内的ICC为0.892、0.937。结论：正常成人斜坡骨髓ADC值、rADC与脑干ADC值的测定在观察者间、观察者内具有很高的一致性。脑干ADC值具有很高的重复性，可作为斜坡骨髓rADC的可靠内源性参照。
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