老年人抗梅毒螺旋体抗体检测分析

摘要

Objective To investigate the reasons for the elderly and the probability of false -positive serum syphilis antibodies ap-pear. Method Using enzyme-linked immunosorbent assay( DLISA)in 6058 patients serum antibodies to syphilis screening in the elderly o-ver the age of 60,positive reviewed with treponema particle agglutination test( TPPA). And 15,224 cases of young screening as con-trol. Results 6 058 elderly patients by DLISA were found 235 cases of syphilis,TPPA method confirmed only 145 cases,false positive rate was 1. 49‰.Compared with the youth group,DLISA method detection rate was statistically significant( P<0. 01),while the TPPA method detec-tion rate was not statistically significant(P﹥0. 05). Conclusion The elderly syphilis detection by DLlSA method is easy to appear false posi-tives,positive samples should be confirmed by TPPA method to improve the accuracy of detection of syphilis.%目的：探讨老年人血清梅毒抗体假阳性结果出现的几率及原因。方法：采用酶联免疫吸附试验（ DLISA）对6058例60岁以上老年人血清梅毒抗体进行初筛，阳性者再用密螺旋体颗粒凝集试验（ TPPA）复查。并以15224例青年筛查对象为对照。结果：6058例老年人DLISA法共检出235例梅毒阳性，TPPA法确诊仅145例，假阳性率为1.49‰。与青年组比较，DLISA法检出率差异有统计学意义（P<0.01），而TPPA法检出率差异无统计学意义（P﹥0.05）。结论：老年人梅毒检测DLlSA 法易出现假阳性，阳性者应用TPPA法进行确认，以提高梅毒检出的正确率。