血清降钙素原、C －反应蛋白、肿瘤坏死因子－α对新生儿败血症的诊断价值

摘要

目的：探讨 C －反应蛋白（CRP）、降钙素原（PCT）、肿瘤坏死因子－α（TNF －α）对于新生儿败血症的诊断价值。方法：选取新生儿败血症患者46例作为试验组，并以40例健康新生儿作为对照组。检测并比较两组患儿血清中的 CRP、PCT、TNF －α的平均水平。使用 SPSS19.0分析比较数据，并用 ROC 曲线评价这三个指标对新生儿败血症的诊断价值。结果：试验组 CRP、PCT、TNF －α水平均明显高于对照组，差异具有统计学意义（P ＜0.01）。CRP 的灵敏度、特异度都达到了100％；PCT 的灵敏度为97.50％，特异度为100％；TNF －α的灵敏度为95.00％，特异度为94.44％。结论：CRP、PCT、TNF －α都可以用于新生儿感染性疾病的诊断，在三者中 CRP 的诊断价值高于 PCT 和 TNF －α。%Objective To investigate CRP,PCT,TNF -αto provide guidance on the diagnosis of neonatal septicemia.Meth-od 46 hospitalized neonates with septicemia were selected as the experimental group and 40 healthy neonates were selected as the control group.The level of blood CRP,PCT,TNF -αof the two groups were detected and compared.Data were analyzed and compared by SPSS 19.0,and the ROC curves were used to judge the value of the three indicators for the diagnosis of neonatal in-fection.Results The levels of CRP,PCT,TNF -αin the experimental group were higher than those in the control group,and the difference was statistically significant(P <0.01).Sensitivity and the specificity of CRP reached 100%,while the sensitivity of PCT was 97.50% and its specificity was 100%.And the sensitivity of TNF -αwas 95.00%,and its specificity was 94.44%.Conclusion CRP,PCT,TNF -αcan all be used to diagnose neonatal septicemia,but CRP is the best indicator in diagnosis of neonatal septicemia among the three indicators.