Objective To investigate the association between inflammatory response and recurrence of atrial fibrillation(AF) within 1 month after radiofrequency catheter ablation(RFCA). Methods Of 54 AF patients underwent RFCA, 22 cases(group A) had a recurrence of AF within 1 month after RFCA and 32 cases( group B) did not. Serum concentrations of high sensitive C-reactive protein (hs-CRP) were measured before,at 3 days,l week,2 weeks and 1 month after ablation. Results Compared to before, serum levels of hs-CRP were significantly increased within 1 month after RFCA (P<0. 05). On the 3rd day, in the 1st week and 2nd week after ablation, serum levels of hs-CRP were significantly higher in group A than those in group B [(19. 2 + 5. 7) mg/L vs. (15. 2 + 6. 0) mg/L, (53.2+9.7) mg/L vs. (46.3 + 8.5) mg/L and (23.8 + 7.8) mg/L vs. (19.8 + 6.1) mg/L] (P<0. 05). The binary logistic regression analysis showed that the maximum difference of before and after RFCA in hs-CRP was an independent risk factor for AF recurrence within 1 month. Conclusion The patients with AF recurrence within 1 month after RFCA has a higher serum hs-CRP level, which indicates that acute inflammatory response induced by ablation may be responsible for myocardiac injury after RFCA.%目的 探讨阵发性心房颤动(房颤)射频消融术后1个月内复发与炎症反应的关系.方法 54例阵发性房颤患者初次行射频消融术.根据术后1个月内是否复发分为复发组(A组,22例)和未复发组(B组,32例).测定术前、术后3d、1周、2周和1个月超敏C反应蛋白(hs-CRP)水平.结果 两组术后的hs-CRP均明显高于术前(P＜0.05).A组术后3d、1周和2周的hs-CRP均明显高于B组[(19.2±5.7) mg/L vs.(15.2±6.0) mg/L、(53.2±9.7) mg/L vs.(46.3±8.5)mg/L和(23.8±7.8) mg/L vs.(19.8±6.1)mg/L](P＜0.05).多因素回归分析显示,hs-CRP手术前后最大差值是房颤术后1个月内复发的独立危险因素.结论 房颤术后1个月内复发的患者hs-CRP明显升高,提示射频消融损伤心肌组织引起的急性炎症过程可能是其重要机制.
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