无创通气对支气管哮喘急性发作的疗效及对血清CRP、IL-6的影响

摘要

Objective To explore the clinical efficacy of NIPPV assisted treatment for acute attack of bronchial asthma and its possible mechanism.Methods 100 cases of moderate-severe acute attack of bronchial asthma in our hospital fiom June 2013 to December 2015 were selected in the study,and randomly divided into experimental group and control group.Control group was treated with routine medication,experimental group was treated with NIPPV on the basis of control group for 3 d.FEV1,FEV1/FVC,PEF,CRP,IL-6,and clinical symptoms before and after treatment of two groups were compared.Results After treatment,whoop alleviating time,wheezing role disappearing time,and hospitalization time in experimental group were significantly shorter than those in control group (P＜0.05).FEV1,FEV1/FVC％,PEF after treatment improved significantly in both groups,and the improvement degree in experimental group were much bigger (P＜0.05).CRP,IL-6 after treatment decreased significantly in both groups,and the changes in experimental group were much bigger (P＜0.05).Conclusion NIPPV can effectively improve clinical symptoms and lung function of acute attack of bronchial asthma.%目的 探讨无创机械通气对支气管哮喘急性发作的临床疗效及其可能机制.方法 选择2013年6月至2015年12月间在本院确诊并治疗的中重度支气管哮喘急性发作的患者作为研究对象,随机分为试验组及对照组.两组患者均接受常规治疗,试验组在此基础上进行无创机械通气,共3d.比较两组患者治疗前后,第一秒用力呼气容积(FEVl)、FEVl/用力呼气肺活量(FVC)、呼气峰流量(PEF)、血清C-反应蛋白(C-reactive protein,CRP)、白细胞介素-6(IL-6)及临床症状改善情况.结果 治疗后,试验组平均喘息缓解时间、平均哮鸣音消失时间及平均住院时间均显著短于对照组,两组比较差异有统计学意义(P＜0.05).两组患者治疗后,FEV1、FEVl/FVC％及PEF均较治疗前显著改善,但试验组改善程度更大,两组比较差异均有统计学意义(P＜0.05).两组患者血清中CRP及IL-6均显著下降,但试验组下降程度更大,两组比较差异均有统计学意义(P＜0.05).结论 无创通气可有效改善支气管哮喘急性发作期的临床症状及肺功能,值得临床推广.