宫颈癌经腔内微波热疗联合放疗后的病理及肿瘤抗原改变

摘要

目的 探讨热放疗对宫颈癌病理组织学及鳞状上皮细胞癌相关抗原(squamous cell carcinoma antigen,SCC)的改变.方法 将Ⅰb期宫颈鳞癌患者66例随机分为两组.实验组32例在常规的腔内放疗的基础上同期增加宫颈腔内微波热疗,2周后行官颈癌根治术;对照组34例接受常规的腔内放疗,2周后行根治术.比较两组术后病理组织学及SCC改变.结果 1、实验组癌细胞出现中重度放疗反应为87.50％,优于对照组的61.76％(P＜0.05);实验组癌周炎症细胞中重度反应为84.37％,优于对照组的55.88％(P＜0.05);实验组癌周纤维组织中重度反应为75.00％,优于对照组的50.00％(P＜0.05).2、实验组SCC降低率为87.50％,高于对照组的52.94％(P＜0.05).结论 1、官颈癌术前放热疗能增强放疗对癌细胞的杀伤作用,加重癌周炎性细胞及纤维细胞反应.2、官颈癌热放疗能较单纯放疗有效降低SCC水平.%Objective To investigate the changes of pathology and squamous cell carcinoma antigen (SCC) in uterine cervix cancer with thermoradiothrapy.Methods 66 patients with stage I b uterine cervix cancer were randomly divided into two groups.32 cases in experimental group underwent thermoradiothrapy on the basis of intracavitary radiotherapy,and radical correction of uterine cervix cancer 2 weeks later.Compared pathohistology and SCC changes of two groups.Results 1.The incidence of middle to severe radiotherapy response of cancer cells was 87.50％ in experimental group,better than 61.76％ in control group (P＜0.05);the incidence of middle to severe radiotherapy response of inflammatory cells nearby the carcinoma was 84.37％ in experimental group,better than 55.88％ in control group (P＜0.05);the incidence of middle to severe radiotherapy response of fiber texture nearby the carcinoma was 75.00％ in experimental group,better than 50.00％ in control group (P＜0.05).2.The reduction rate of SCC was 87.50％ in experimental group,higher than 52.94％ in control group (P＜0.05).Conclusions l.Thermoradiotherapy can improve the lethal effect to malignant cells and the response of inflammatory ceils.2.Pre-operative thermoradiothrapy can depress SCC in utedne cervix cancer patients.