高血压早期肾损害检测血清相关因子和尿微量白蛋白肌酐比值的诊断价值

摘要

Objective To investigate the diagnostic values of serum cystatin C (Cyst-C),urinary albumin to creatinine ratio (UACr),and endothelin-1 (ET-1) in early renal damage of hypertension.Methods From February 2015 to September 2016 at our hospital,94 patients with primary hypertension were enrolled as an observation group and 90 non-hypertensive patients a control group.According to the renal dynamic imaging,each group was dividerinto 2 subgroups,an early renal damage group and a normal renal function group.The observation indexes were focused on the serum Cyst-C,ET-1,and UACr.Results The serum levels of Cyst-C,UACr,and ET-1 were higher in the observation group than in the control group,with a significant increasing tendency as increment of blood pressure (P ＜ 0.05).The combined detection rate of serum Cyst-C,UACr,and ET-1 was higher than that individually (P ＜ 0.05).The serum levels of Cyst-C,UACr and ET-1 were higher in the observation group than in the control group in the patients with early renal damage (P ＜ 0.05).Conclusions The serum levels of Cyst-C,UACr,and ET-1 increase with the progression of early renal damage in hypertensive patients;these indexes can be used as effective diagnostic factors for early renal damage and can improve the diagnostic value.%目的 探讨高血压早期肾损害检测血清胱抑素C(Cyst-C)、尿微量白蛋白肌酐比值(UACr)和内皮素-1(ET-1)的诊断价值.方法 选取2015年2月至2016年9月本院收治的94例原发性高血压患者为观察组,另选同期90例非高血压患者为对照组,按肾动态显像是否正常将两组各分为早期肾损害和肾功能正常两个亚型,均行血清Cyst-C、ET-1及尿UACr测定,观察对比各组血清Cyst-C、ET-1及尿UACr水平.结果 观察组血清Cyst-C、UACr及ET-1水平高于对照组,且随血压升高呈现显著增高趋势,差异有统计学意义(均P＜ 0.05);血清Cyst-C、UACr及ET-1联合检测阳性率高于各项单一检测,差异有统计学意义(均P＜ 0.05);观察组早期肾损害患者血清Cyst-C、UACr及ET-1水平均高于对照组早期肾损害患者,差异有统计学意义(均P＜ 0.05).结论 血清Cyst-C、UACr及ET-1水平均随高血压早期肾损害病情发生进展呈现升高趋势,可作为早期肾损害有效诊断指标,能提高诊断价值.