Retrospective feline studies have shown SDMA is more sensitive than sCr for early CKD detection. Our objective was to compare SDMA and sCr for detection of early CKD in a prospective, longitudinal study of older dogs.SDMA and traditional serum and urine clinicopathologic tests were measured biannually for four years in 43 dogs with an initial median age of 8.9 years. Persistent increases in UPC, sCr, or SDMA or decreases in USG triggered renal ultrasound (US) and GFR (plasma iohexol clearance) evaluations. Necropsies were performed whenever possible when dogs died or were euthanized.
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