雾化吸入高剂量布地奈德治疗重度哮喘患儿的疗效及对其血清细胞因子水平的影响

摘要

目的 探讨雾化吸入高剂量布地奈德治疗重度哮喘患儿的疗效及对其血清细胞因子水平的影响.方法 选取本院87例重度哮喘息儿,按随机数字表法分为对照组43例,观察组44例.对照组雾化吸入100μg/d布地奈德治疗;观察组雾化吸入800μg/d布地奈德治疗,观察比较两组治疗效果及白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-d)水平.结果 观察组治疗总有效率为86.36％(38/44),高于对照组67.44％(29/43),差异有统计学意义(P＜0.05);治疗后观察组IL-4及TNF-α水平均低于对照组,差异有统计学意义(P＜0.05);观察组不良反应发生率为13.64％(6/44),对照组为9.30％(4/43),组间比较差异无统计学意义(P＞0.05).结论 对重度哮喘患儿给予高剂量布地奈德雾化吸入,效果显著,可有效改善患儿血清细胞因子水平,安全性高.%Objective To explore the efficacy of the aerosol inhalation of a high dose of budesonide for children with severe asthma and its effect on serum cytokine levels.Methods 87 children with severe asthma were randomly divided into a control group (n=43) and an observation group (n=44) using random number table method.The control group aerosolly inhaled budesonide 100 μg/d and the observation group 800 μg/d.The levels of Interleukin-4 (IL-4) and tumor necrosis factor-α (TNF-αt) in the two groups were observed and compared.Results The total efficacy was 86.36％ (38/44) in the observation group and was 67.44％ (29/43) in the control group,with a statistical difference (P ＜ 0.05).After the treatment,the levels of IL-4 and TNF-alpha were lower in the observation group than in the control group,with statistical difference (both P ＜ 0.05).The incidence of adverse reactions was 13.64％ (6/44) in the observation group and was 9.30％ (4/43) in the control group,with no statistical difference (P ＞ 0.05).Conclusions The aerosol inhalation of a high dose of budesonide for children with severe asthma is quite effective and safe and can the children's serum cytokine levels.