胃食管反流病发病机制及相关遗传基因研究进展

摘要

胃食管反流病(GERD)发病机制复杂,临床上治疗也相对棘手.目前认为食管裂孔疝、食管下括约肌功能异常、食管动力障碍、食管黏膜屏障功能受损、胃内酸袋、精神心理因素等方面参与了GERD的发病.随着对GERD研究的深入,IL-1 β、IL-1RN、CYP2C 19、GNB3、GSTs、ABAT、HLA、PAR-2等遗传基因多态性被认为是GERD的易感因素.全面理解GERD的发病机制及遗传基因多态性将有助于该病的预防及治疗.%The pathogenesis of gastroesophageal reflux disease is complicated and the clinical treatment is relatively difficult.It is currently considered that esophageal hiatal hernia,dysfunction of the lower esophageal sphincter,esophageal motility disorders,impaired esophageal mucosal barrier function,acid pocket,mental and psychological factors were involved in the attack of gastroesophageal reflux disease.With the further study of gastroesophageal reflux disease,genetic polymorphisms of IL-1β,IL-1RN,CYP2C 19,GNB3,GSTs,ABAT,HLA,PAR-2 are considered as susceptibility factors of gastroesophageal reflux disease.A comprehensive understanding of the pathogenesis and genetic polymorphisms of gastroesophageal reflux disease will contribute to the prevention and treatment of the disease.