关于强心苷类药物与无义介导的mRNA降解在抗肿瘤作用中的研究

摘要

Cardiac glycosides are known to inhibit the Na+/K+ ATPase pump. The inhibition results in the release of intracellular calcium and consequently increasing myocardial contractile force. Besides this, several studies have shown that cardiac glycosides possess anticancer effects by binding to Na+/K+ ATPase. Nonsense-mediated mRNA decay (NMD) is an eukaryotic cellular mRNA surveillance mechanism that degrades mRNA transcripts containing premature termination codons, and is considered related to cancer. Recent studies show that cardiac glycosides have effects on the NMD pathway. This review aims at discussing the relationship between cardiac glycosides, nonsense-mediated mRNA decay and their anticancer effects.%强心苷是一类具有强心作用的甾体苷类化合物，其可抑制心肌细胞膜上的Na+/K+ ATP酶，通过降低质膜两侧Na+的浓度差以减小Na+-Ca2+交换的驱动力，使胞质内Ca2+浓度增加，从而产生强心效应。强心苷与细胞膜上Na+/K+ ATP酶特异性结合，一方面可抑制其离子通道作用，另一方面在较低浓度下可调控下游信号通路，近来研究表明，其可能具有抗肿瘤效应。无义介导的mRNA降解(nonsense-mediated mRNA decay，NMD)是近年发现的RNA监控机制，被认为与肿瘤的发生发展有关。本文旨在探讨强心苷、NMD与肿瘤之间的相互关系，为肿瘤的治疗提供新思路。