新生儿缺氧缺血性脑病血小板参数动态变化的Meta分析

摘要

Objective To investigate the relationship between the dynamic changes of platelet parameter and the severity of the neonatal hypoxia ischemic encephalopathy .Methods To search PubMed ,Ovid ,Springer Database ,Chinese Academic Journal ,VIP database and Wanfang database in the library literature and screen documents according to the inclusion criteria of diagnostic tests , then to extract the characteristic information .Using RevMan 5 .1 software to analyze the data ,and to carry out the Meta analysis se-lected the effects model according the results of tests for heterogeneity .Results According to the inclusion criteria ,it was won the 10 articles eventually .The Meta analysis results showed that the PLT in acute period of HIE patients was significantly 1 .65-2 .14 times the standard deviation lower than the control group .The MPV and PDW in acute period of HIE patients were significantly 1 .12-1 .61 and 1 .17-1 .99 times the standard deviation higher than the control group .The PLT in convalescent of HIE patients was 1 .85-2 .35 times the standard deviation higher than the acute period of HIE patients .The MPV and PDW in the convalescent of HIE patients were significantly 0 .68-1 .38 and 0 .81-1 .37 times the standard deviation lower than the acute period of HIE pa-tients .Obviously ,the PLT ,MPV and PDW in the convalescent of HIE patients were closed to the level of the control group .Conclu-sion Clinical observing HIE infant′s platelet parameter dynamically can be regarded as the index of HIE infant′s condition severity and monitoring condition change .%目的：探讨血小板参数的动态变化与新生儿缺氧缺血性脑病（HIE）病情程度的关系。方法检索PubMed、Ovid、Springer数据库，以及中国期刊全文数据库、维普中文科技期刊数据库和万方期刊数据库的在库文献，按照诊断试验的纳入标准筛选文献，提取纳入研究的特征信息。数据分析采用RevM an 5．1软件，根据结果选择相应效应模型进行M eta分析。结果按照纳入标准，最终获得10篇文献。Meta分析结果表明，急性期 HIE患者血小板值明显低于对照组1．65～2．14倍的标准差，而M PV、PDW值明显高于对照组1．12～1．61和1．17～1．99倍标准差。恢复期 HIE患者比急性期 HIE患者血小板值高1．85～2．35倍标准差，而M PV、PDW值则明显低于急性期HIE患者0．68～1．38和0．81～1．37倍标准差，接近健康新生儿的水平。结论临床动态观察 HIE患儿的血小板参数，可作为判断 HIE的严重程度及监测病情变化的指标之一。