Objective To investigate the significance of combined detection of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and small dense low-density lipoprotein cholesterol (sdLDL-C) in the clinical diagnosis of coronary heart disease.Methods 100 patients with coronary heart disease were selected as the ex-periment group ,and 50 healthy subjects who underwent the health assessment were selected as the control group.The levels of serum Lp-PLA2 ,sdLDL-C ,homocysteine (Hcy) ,triglyceride (TG) ,total cholesterol (TC) ,high density lipoprotein cholesterol (HDL-C) ,low density lipoprotein cholesterol (LDL-C) ,and the de-gree of coronary heart disease (CHD) were measured and the correlation was analyzed.Results Compared with the control group ,the level of Lp-PLA2 ,sdLDL-C and Hcy increased significantly ,and the level of HDL-C was lower ,and the difference was statistically significant (P＜0.05) ;there was a positive correlation between Lp-PLA2 and sdLDL-C ,Hcy ,TG ,TC and LDL-C (r=0.430 ,0.633 ,0.259 ,0.450 ,0.269 ,P=0.026 , 0.013 ,0.028 ,0.032 ,0.023).There was a negative correlation between Lp-PLA2 and HDL-C (r= -0.632 , P=0.01).In 0- ＜20 points ,20- ＜40 points and ≥40 points experiment groups ,the levels of Lp-PLA2 and sdLDL-C were significantly higher than those in the control group ,and the differences were significant (P＜0.05) ;there was also a significant difference in the level of Lp-PLA2 and sdLDL-C between 0- ＜20 points ,20- ＜40 points and ≥40 points experiment groups (P＜0.05).The positive rates of the combined detection of Lp-PLA2 and sdLDL-C in the acute coronary syndrome (ACS) group and the stable angina (SAP) group were significantly higher than those of the single test ,and the differences were statistically significant (χ2=4.246 , 4.974 ,P=0.039 ,0.026).Conclusion Lp-PLA2 and sdLDL-C levels are both higher in patients with coronary heart disease than those in healthy people.The combined detection of Lp-PLA2 and sdLDL-C has a certain clinical significance for assessing the development and prognosis of patients with coronary heart disease.%目的 探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2) 、小而密低密度脂蛋白胆固醇(sdLDL-C)联合检测在冠心病患者临床诊断中的意义.方法 选择冠心病患者100例作为冠心病组,健康体检者50例作为对照组,分别检测血清Lp-PLA2 、sdLDL-C 、同型半胱氨酸(Hcy)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C) 、低密度脂蛋白胆固醇(LDL-C)的水平及冠心病病变程度,并分析其相关性.结果 与对照组相比,冠心病组Lp-PLA2 、sdLDL-C及 Hcy水平明显升高,HDL-C水平较低,差异有统计学意义(P＜0.05) ;Lp-PLA2与sdLDL-C 、Hcy 、TG 、TC 、LDL-C水平呈正相关关系(r=0.430 、0.633 、0.259 、0.450 、0.269 ,P=0.026 、0.013 、0.028 、0.032 、0.023) ;Lp-PLA2与 HDL-C呈负相关关系(r= -0.632 ,P=0.01) ;冠心病组中0~ ＜20分和20~ ＜40分及≥40分的Lp-PLA2和sdLDL-C水平均明显高于对照组,差异有统计学意义(P＜0.05) ;且0~ ＜20分和20~ ＜40分及≥40分患者的Lp-PLA2 、sdLDL-C水平比较,差异也有统计学意义(P＜0.05).急性冠状动脉综合征(ACS)组和稳定型心绞痛(SAP)组Lp-PLA2与sdLDL-C联合检测的阳性率均明显高于单项检测,差异有统计学意义(χ2=4.246 、4.974 ,P=0.039 、0.026).结论 冠心病患者Lp-PLA2与sdLDL-C水平较健康体检者明显升高,二者的联合检测对评估冠心病患者的病情发展及预后有一定的临床意义.
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