巨噬细胞极化与人类免疫缺陷病毒感染

摘要

极化是免疫系统进行免疫调节,发挥不同功能的重要策略.巨噬细胞作为固有免疫的重要组成部分和免疫调节者,其极化会对后续的免疫反应产生深刻的影响.巨噬细胞是HIV靶细胞,不同的极化方向也必然会影响对HIV感染的敏感性.同时,HIV感染导致宿主免疫功能紊乱也不可避免地影响到巨噬细胞正常的极化.本文就巨噬细胞极化与HIV感染相互关系的研究进展进行概述.%Polarization is an important strategy of immunoloregulation by which immune system develops different functions. As an important component of innate immunity and modulator of immunity as well as target cells of HIV, polarization of marcrophages will substantially influence subsequent immune response and susceptibility to HIV. Meanwhile, immune functional disorder caused by HIV infection will also impact normal polarization of marcrophages. The review focuses on the current progress of studies on the correlations between macrophage polarization and HIV infection.