目的 比较3种β-内酰胺酶抑制药的作用强弱;观察青霉素类抗生素/他唑巴坦对临床分离的致病菌的体外抗菌活性.方法 采用二倍稀释法,检测这几种抗菌药物对临床分离致病菌的体外抗菌活性.结果 他唑巴坦的酶抑制作用最强.阿莫西林与他唑巴坦,阿洛西林与他唑巴坦,美洛西林与他唑巴坦联合后,对于金黄色葡萄球菌、表皮葡萄球菌、大肠埃希菌等MIC50比单用分别低93.75%,96.88%,93.75%.结论 加入他唑巴坦后,青霉素类抗生素的抗菌活性显著提高.%Objective To compare the efficacy of three β-1actamase inhibitors and investigate in vitro anti-bacterial activity of penicillins/tazobactam against pathogens isolated from patients. Methods The minimum inhibitory concentrations ( MIC ) of the anti-bacterial agents against clinically isolated strains was detected by the agar dilution method. Results It was indicated that tazobactam showed the most powerful β-1actamase inhibition. The MIC50 of amoxicillin /tazobactam, azlocillin/tazobactam and mezlocillin/tazobactam against the common pathogens like Staphylococcus aureus, Staphylococcus epidermidis and E. coli was 93.75 ％ , 96. 88 ％ , 93.75％ lower than the single use, respectively. Conclusion The in vitro antibacterial activities of penicillins are significantly improved in combination with tazobactam.
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