辛伐他汀与灯盏花素联合治疗对冠心病患者血液流变学及LPO、SOD的影响

摘要

目的：研究辛伐他汀与灯盏花素联合治疗对冠心病（ CHD）患者血液流变学指标、血清脂质过氧化物（ LPO）及超氧化物歧化酶（ SOD）的影响。方法将140例CHD患者随机分成观察组和对照组，每组各70例，在治疗前与治疗后的第14 d检测患者血液流变学指标、LPO及SOD水平变化。结果观察组总有效率为97.1％。对照组为75.7％，两组疗效比较，差异有统计学意义（ P＜0.05）；观察组血液流变学指标较治疗前明显改善，接近正常水平，对照组血液流变学亦有改善，但不如观察组明显；观察组LPO明显下降、SOD明显升高，治疗前后比较，差异有统计学意义（ P＜0.05），对照组无明显改善。结论辛伐他汀与灯盏花素联合治疗可明显改善CHD患者的血液流变学指标，提高SOD水平，降低LPO水平，临床治疗效果较好。%Objective To evaluate the influence of Simvastatin with Breviscapine treatment on patients with Coronary Heart Disease and study the changes of hemorheology and Lipoperoxides ( LPO) and Superoxide dismutase ( SOD) .Methods 140 patients were randomly divided into the observation group(Simvastatin with Xueshuantong) and the control group(Simvastatin),the hemorheology,LPO level and SOD level before and after treatment 14 days were detected .Results The total effective rate of the observation group was 97.1%,and the total effective rate of the control group was 75.7%,there was asignificant difference in the two groups ( P<0.05 );the observation group were close to normal levels and that of the control group were only improved ;LPO level reduced and SOD level rose clearly ( P<0.05 ) and there was no improvement in the control group .Conclusion Simvastatin with Breviscapine treatment on patients with Coronary Heart Dis-ease could improve the hemorheology ,reduce the level of LPO , rise the level of the SOD ,and get outstanding clinical efficacy .