下颌骨边缘性切除术在涉及下颌骨的口腔鳞癌中的应用

摘要

目的：：研究下颌骨边缘性切除术( MMR)在涉及下颌骨的口腔鳞癌中的应用。方法：选择从2010年5月到2013年6月在榆林市第一医院接受手术治疗的口腔鳞癌患者98例作为研究对象。根据手术方案的不同将患者分成观察组(给予MMR)48例及对照组(给予下颌骨节段切除术)50例，比较两组患者的临床情况，手术指标，患者的1~3年生存率及复发率，以及患者术后对颜面部评分。结果：两组患者的病理分级、pT分期、下颌骨受累及淋巴结转移等临床情况相比，差异均无统计学意义( P>0.05)。观察组的手术时间和术中出血量，以及切口距离瘤灶的长度和住院时间与对照组相比，差异均无统计学意义( P>0.05)。观察组的1~3年生存率及复发率与对照组相比，差异均无统计学意义( P>0.05)。观察组患者术后的整体自视、生活适应、社会评价以及综合评分均分别高于对照组，差异有统计学意义( P<0.05)。结论：MMR治疗涉及下颌骨的口腔鳞癌患者的效果及安全性较好，但临床应关注其适应证。%Objective: To investigate the application of mandibular marginal resection of mandible in-volved in oral squamous cell carcinoma. Methods:98 patients with oral squamous cell carcinoma who received surgical treatment from May 2010 to June 2013 were selected as the study subjects. According to the different operation scheme was divided into observation group ( given mandibular marginal resection) 48 cases and the control group (given mandibular segmental resection)50 cases, the clinical situation, operation index, 1 ~ 3 year survival rate and recurrence rate of patients in the two groups were compared. Results:The two groups of patients with pathological grade, pT stage, mandible affected by lymph node metastasis and other clinical ca-ses, the difference was not statistically significant (P > 0.05).In the observation group, the operation time and the amount of bleeding during operation, and the length of the distance between the tumor and the length of stay in hospital and the control group, the difference was not statistically significant ( P >0.05) . The obser-vation group of 1 ~ 3 years survival rate and recurrence rate compared with the control group, the difference was not statistically significant ( P >0.05) . Observation group patients after the overall self-esteem, life adap-tation, social evaluation and comprehensive score were significantly higher than the control group, the differ-ence was statistically significant (P < 0.05).Conclusion:Mandibular marginal resection therapy involves the efficacy and safety of mandible in oral squamous cell carcinoma patients is better, but the clinical attention to its indications.