猴头菌提取物颗粒治疗小儿感染后脾虚综合征106例分析

摘要

目的:探讨猴头菌提取物颗粒治疗小儿感染后脾虚综合征的临床疗效.方法:选取2016年1月至2016年12月106例小儿感染后脾虚综合征患者,根据随机数字法,将其分为对照组(双歧杆菌乳杆菌三联活菌片,48例)和观察组(对照组治疗基础上,给予猴头菌提取物颗粒,58例),比较两组治疗的总体疗效、治疗前后体液免疫及细胞免疫指标变化情况.结果:与对照组相比,观察组治疗的总有效率明显增高(96.6%vs70.8%,P<0.05),差异有统计学意义;与对照组相比,观察组明显改善患儿体液免疫功能,治疗后IgG、IgA水平均明显增高(P<0.05),差异有统计学意义;与对照组相比,观察组有效改善患儿细胞免疫功能,治疗后CD3、CD4、CD4/CD8水平均明显增高(P<0.05),差异有统计学意义.结论:猴头菌提取物颗粒能够明显改善感染后脾虚综合征患儿免疫功能,提高治疗的临床疗效.%Objective:To study the clinical efficacy of hedgehog fungus extract granules in the treatment for spleen deficiency syndrome after infection in children. Methods:The 106 children patients with spleen de-ficiency syndrome after infection in our hospital during the period from Jan 2016 to Dec 2016 were randomized into the control group ( treatment of live combined Bifidobacterium and Lactobacillus tablets,48 patients) and the observation group ( addition to control group,treatment of hedgehog fungus extract granules,58 patients) according to the random number method. The total clinical efficacy,the changes of humoral immunity and cel-lular immunity pre- and post-treatment in two groups were compared. Results: Compared with the control group,the total effective rate of treatment was significantly increased in the observation group with statistical difference (96.6% vs 70.8%,P<0.05);compared with the control group,the humoral immune function wasobviously improved and the levels of IgG and IgA on post-treatment were significantly increased in the obser-vation group with statistical difference ( P<0.05);compared with the control group,the cellular immune func-tion was obviously improved and the levels of CD3,CD4,CD4/CD8 on post-treatment were significantly in-creased in the observation group with statistical difference ( P<0.05) . Conclusion:The treatment of hedgehog fungus extract granules can significantly improve the immune function for spleen deficiency syndrome after in-fection in children and increase the clinical efficacy of treatment.