目的 观察消瘤化积肠方Ⅰ号配合化疗治疗大肠癌根治术后的临床疗效.方法 将64例大肠癌术后患者随机分为2组,对照组32例予FOLFOX方案化疗,治疗组32例在对照组治疗基础上加消瘤化积肠方Ⅰ号,连续服用5个月.观察2组患者治疗前后患者生活质量及免疫学指标变化情况,化疗不良反应发生情况及肿瘤复发转移情况.结果 治疗组生活质量改善率(78.1％)优于对照组(62.5％,P＜0.05)；恶心呕吐、白细胞减少、神经毒性及肝功能损害发生严重程度较对照组轻(P＜0.05)；复发转移率(18.75％)低于对照组(34.38％,P＜0.05).治疗组治疗后CD4、CD8、自然杀伤细胞(NK)及白细胞介素-2(IL-2)水平均较本组治疗前明显提高(P＜0.05),且明显高于对照组治疗后(P＜0.05).结论 消瘤化积肠方Ⅰ号配合化疗治疗大肠癌根治术后,能改善患者生活质量,提高免疫功能,并能减轻化疗的毒副反应.%Objective To observe the clinical efficacy of combination of Xiaoliuhuaji Decoction I and chemotherapy on the treatment of postoperative colorectal cancer. Methods A total of 64 patients with postoperative colorectal cancer were randomly divided into two groups: control group in which 32 cases were treated by FOLFOX regimen and treatment group in which 32 cases were treated by combined "Xiaoliuhuaji Decoction I " and FOLFOX regimen. The quality of life, immune function, toxic reaction, carcinoembryonic antigen (CEA) level and the recurrence and metastasis of cancer in the two groups were observed. Results The quality of life and cellular immunity was higher and the incidence of toxic reaction was lower in treatment group than that in control group (P < 0. 05 ). Conclusion Combination of Xiaoliuhuaji Decoction I and chemotherapy can reduce toxicity and improve the quality of life and cellular immunity on the treatment of colorectal cancer after radical treatment.
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